Company: Astellas Pharma Co. Ltd.
Legal category: Prescription. HT. Sport Permitted.
Active ingredient: Tacrolimus 0.5mg, 1mg, 5mg.
Description: Yellow-orange, white-orange, greyish red-orange gelatin capsules imprinted in red with 0.5mg, 1mg, 5mg on the capsule cap and *647, *677, *687 respectively on the orange capsule body.
Presentation: 50, price available on request.
Indications: Prophylaxis of transplant rejection in adult kidney or liver allograft recipients. Treatment of allograft rejection resistant to treatment with other immunosuppressive medicinal products.

Pharmacology: Tacrolimus is a highly potent immunosuppressant. In particular, it inhibits the formation of cytotoxic lymphocytes, which are mainly responsible for graft rejection.
Dosage: Should only be prescribed by physicians experienced in immunosuppressive therapy and the management of transplant patients. Adult: Swallow with fluid (preferable water) once daily in the morning on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal. Prophylaxis of transplant rejection: Commence at 0.20-0.30 mg/kg/day (kidney) or 0.10-0.20mg/kg/day (liver). Doses are usually reduced in the post-transplant period. Stable patients converting to once-daily Advagraf from twice-daily Prograf should be converted on a 1:1 (mg:mg) total daily dose basis. See SPC for further recommendations. Elderly: As per adults. Children: Not recommended.
Contraindications: Hypersensitivity to tacrolimus or other macrolides or to any of the excipients. Lactation.
Special precautions: Severe liver impairment (consider dose reduction). Black patients may require higher tacrolimus doses to achieve similar trough levels. Converting from ciclosporin-based to tacrolimus-based therapy (caution). During the initial post-transplant period, monitor BP, ECG, neurological and visual status, fasting blood glucose levels, electrolytes (particularly K+), liver and renal function tests, haematology parameters, coagulation values, and plasma protein determinations. If clinically relevant changes are seen, adjust immunosuppressive regimen. EBV-associated lymphoproliferative disorders, ventricular hypertrophy or hypertrophy of the septum reported (monitor high-risk patients). Diagnosed or suspected Congenital Long QT Syndrome. Limit exposure to sunlight and UV light. Contains lactose. Pregnancy (if benefit outweighs risk).
Drug interactions: Tacrolimus is a known substrate and inhibitor of CYP3A4. Avoid herbal preparations including St. John’s wort, ciclosporin, grapefruit juice. Caution: Inhibitors/inducers/substrates of CYP3A4 (see Appendix I). Drugs known to have nephrotoxic or neurotoxic effects (e.g. aminoglycosides, gyrase inhibitors, vancomycin, cotrimoxazole, NSAIDs, ganciclovir or aciclovir); may increase these effects. Possible interactions with other drugs which like tacrolimus are known to have high affinity for plasma proteins (e.g. NSAIDs, oral anticoagulants, oral antidiabetics).

Adverse drug reactions: GI disorders, renal impairment, hyperglycaemic conditions, diabetes mellitus, hyperkalaemia, insomnia and other psychiatric disorders, tremor, headache, seizures, disturbances in consciousness, paraesthesias and dysaesthesias, peripheral neuropathies, dizziness, nervous system disorders, ischaemic coronary artery disorders, tachycardia, tinnitus, vision blurred, photophobia, eye disorders, respiratory disorders, rash and other skin disorders, arthralgia, muscle cramps, pain in limb/ back, hepatobiliary disorders. Anaemia and other blood disorders.
Full prescribing information and references available from Astellas Pharma Co. Ltd. Telephone: (01) 4671550. Fax: (01) 4671555. E-mail: Andrea.Logue@ie.astellas.com

Почитал я про эти таблетки. Препарат новый, производица в Японии. Нам про него пока можно не думать.

А до этого дня и слыхом не слыхивал про какие то там аукционы...

Стал выяснять в местном центре трансплантации где я состою врач сказал, что ничем помочь не может и рекомендует пить.... а если будет ухудшение состояния сигнализировать им, они попробуют на местное министерство здравоохранения надавить... и что у него уже два больных его пьют и вроде как (именно так и сказал - вроде как) пока все нормально...

Позвонил в Москву к своему лечащему врачу... Сказала, что выдача майсепта - прямое нарушение какого-то закона (какого - после праздников скинет на мэил), они мне выписывали не Микофенолата Мофетил а селсепт и замена незаконна.

Наташа, это надо в подпись, как раз две строчки! Или в телевизор.