Another device available for addition to hemodialysis is the Lixelle cartridge (Kaneka Corp., Osaka, Japan). This device is a column that contains a porous cellulosic bead that covalently binds В2M on ligands. Use of the device along with hemodialysis for periods of 25 to 62 wk resulted in symptomatic improvement and partial radiographic improvement in dialysis-related amyloidosis. Homma N, Gejyo F, Hasegawa S, Teramura T, Ei I, Maruyama H, Arakawa M: Effects of a new adsorbent column for removing beta-2-microglobulin from circulating blood of dialysis patients. Contrib Nephrol 112: 164–171, 1995
а вот более свежие новости от Ронко:
Conventional coated charcoal particles in hemoperfusion devices are unable to remove solutes in the range of 1 to 50 kD; however, recently controlled pyrolization of divinylbenzene polymer beads yielded activated charcoal with pores capable of adsorbing molecules in the middle molecular weight range.18 Similarly, a styrene polymer with an enhanced proportion of mesopores in the range of 2 to 20 nm was shown in a pilot study of humans to remove В2-microglobulin (В2M; 11.8 kD), angiogenin (17 kD), leptin (16 kD), retinol binding protein (21.2 kD), and IL-18 (18 kD).
Winchester JF, Silberzweig J, Ronco C, Kuntsevich V, Levine D, Parker T, Kellum JA, Salsberg JA, Quartararo P, Levin NW: Sorbents in acute renal failure and end stage renal disease: Middle molecule and cytokine removal. Blood Purif 22: 73–77, 2004
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